The role of insomnia and traumatic brain injury in MCI and dementia

 


   Note: An Official Proposal has not been Submitted to NACC.


   Lead Investigator:    Caterina Mosti
   Institution      :    University of California, San Francisco
   E-Mail           :    caterina.mosti@ucsf.edu
   Proposal ID      :    1798



   Proposal Description:
   Both insomnia and traumatic brain injury (TBI) are relatively common in late life, and both have been independently identified as risk factors for the development of MCI and dementia. While emerging data suggests that insomnia and brain injury are highly comorbid and can have negative implications with regard to cognition, mood, and quality of life in military and athlete populations, the prevalence and effects of insomnia in older adults with history of brain injury remains unclear. This study aims to identify the prevalence of self-reported insomnia and history of brain injury in an older adult sample, and to compare indices of cognition, mood, brain MRI, and neuropathological findings among individuals without history of brain injury or insomnia, individuals with only history of TBI or insomnia (but not both), and individuals with both a history of TBI and insomnia. Findings may inform novel treatments for management of prodromal or clinical signs of dementia, and may identify additional factors for individuals at particular risk of MCI and dementia.